Dysbindin

A dystrophin-associated protein and component of the Biogenesis of Lysosomal Organelles Complex-1 (BLOC-1 complex) which is essential for the formation of LYSOSOME - derived organelles such as platelet dense granules and MELANOSOMES. DTNBP1 is expressed primarily in the brain and neurons, where it functions with ADAPTOR PROTEIN COMPLEX 3 to transport membrane proteins to NEURITES and nerve terminals. It also regulates the release of neurotransmitters, transport of synaptic vesicles, and localization of DOPAMINE D2 RECEPTORS. Mutations in the DTNBP1 gene are associated with Type 7 HERMANSKY-PUDLAK SYNDROME and SCHIZOPHRENIA.

Also Known As:

DTNBP1 Protein; Dysbindin-1; Dystrobrevin Binding Protein 1; Hermansky-Pudlak Syndrome 7 Protein; Dysbindin 1; Hermansky Pudlak Syndrome 7 Protein

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Dystrophin-Associated Proteins: 48
      - Dysbindin: 289
    - Vesicular Transport Proteins: 1
      - Dysbindin: 289
  - Cytoskeletal Proteins: 739
    - Dystrophin-Associated Proteins: 48
      - Dysbindin: 289
  - Contractile Proteins: 699
    - Muscle Proteins: 1582
      - Dystrophin-Associated Proteins: 48
        Dysbindin: 289
  - Nerve Tissue Proteins: 2
    - Dysbindin: 289

Hugh Md Gurling Selected Research

Hugh Md Gurling Research Topics

Disease

Drug/Important Bio-Agent (IBA)